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AITHM Seminar: Helminths and type 2 immunity

19 November 2018, 1:00pm - 19 November 2018, 2:00pm

Helminths and type 2 immunity: New insights into protection, tissue repair, and the microbiota.

Location: Cairns D003.144, video link to Townsville 48.202

Zoom meeting ID: 567 762 604

Type 2 immunity is a highly complex system characterized by interleukin (IL)-4, IL-5 and IL-13 production and the recruitment/activation eosinophils, basophils, mast cells and alternatively-activated macrophages (AAM). Much of our understanding of type 2 immune responses derives from the pathological role of this response in driving allergies; however, the physiological role of type 2 immunity is assumed to be the control of helminth parasites. Approximately 2.5 billion people -  living in improvised conditions without adequate access to sanitation – suffer from chronic infection. Yet no vaccines are available and how immune cells trap and kill the parasites remains unclear. Recent data also indicates that helminth-microbiota interactions and can impact on parasite control and inflammatory disease (allergy and metabolic disorders). Our laboratory has been actively engaged in all exploring host-helminth-microbiota interactions with a particular focus on the role of type 2 immunity.


About the presenter

Professor Nicola Harris completed her undergraduate studies and PhD thesis in new Zealand then moved. In to Switzerland as a postdoctoral fellow at the University of Zurich, then later as an Assistant Professor at the ETH Zurich. In August 2009 joined the Swiss Vaccine Research Institute (SVRI), EPFL, Lausanne, where she was promoted to Associate Professor and gained a prestigious ERC starting grant. In 2018 she moved to Melbourne, Australia where she is currently laboratory head and NHMRC senior research fellow, located within the Department of Immunology and Pathology, Monash University, Australia.

 

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